APLN
LOCUS ID8862
GENE_SYMBOLAPLN
GENE NAMEapelin
SYNONYMNSAPEL,XNPEP2
CHROMOSOMEX
HOMOLOGENE ID8498
microRNAsNANA
GENE SUMMARY
This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Apelin level is found significantly higher in diabetic neuropathy group than the diabetic milletus group.Elevated apelin levels may indicate the metabolic state causing diabetic complications.27010147
Retinopathy1. Serum omentin-1 concentration correlates negatively, while serum apelin and chemerin concentrations correlate positively with DR presence and severity in T2DM patients. 31686535