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APLN |
LOCUS ID | 8862 | |||||||||||||
GENE_SYMBOL | APLN | |||||||||||||
GENE NAME | apelin | |||||||||||||
SYNONYMNS | APEL,XNPEP2 | |||||||||||||
CHROMOSOME | X | |||||||||||||
HOMOLOGENE ID | 8498 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. |
OBSERVATIONS |
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Complication | Evidence | PMID |
Neuropathy | 1. Apelin level is found significantly higher in diabetic neuropathy group than the diabetic milletus group.Elevated apelin levels may indicate the metabolic state causing diabetic complications. | 27010147 |
Retinopathy | 1. Serum omentin-1 concentration correlates negatively, while serum apelin and chemerin concentrations correlate positively with DR presence and severity in T2DM patients. | 31686535 |