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APOL1 |
LOCUS ID | 8542 | |||||||||||||
GENE_SYMBOL | APOL1 | |||||||||||||
GENE NAME | apolipoprotein L1 | |||||||||||||
SYNONYMNS | APOL, APO-L, FSGS4, APOL-I | |||||||||||||
CHROMOSOME | 22 | |||||||||||||
HOMOLOGENE ID | 0 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several di |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans. | 26152403 |
Cardiovascular | 1. Although the APOL1 variants are not common in the mixed ancestry population of South Africa, the study does provide an indication that APOL1 variants may play a role in conferring an increased risk for renal and cardiovascular risk in this population. | 26112018 |