| APP |
| LOCUS ID | 351 | ||||||||||
| GENE_SYMBOL | APP | ||||||||||
| GENE NAME | amyloid beta precurs | ||||||||||
| SYNONYMNS | AAA AD1 PN2 ABPP APPI CVAP ABETA PN-II preA4 CTFgamma alpha-sAPP | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 56379 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifunga |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. APP is highly expressed in adipose tissue, upregulated in obesity, and expression levels correlate with insulin resistance and adipocyte cytokine expression levels. | 18483477 |