| APPL1 |
| LOCUS ID | 26060 | |||||||||||||
| GENE_SYMBOL | APPL1 | |||||||||||||
| GENE NAME | adaptor protein, pho | |||||||||||||
| SYNONYMNS | APPL, DIP13alpha | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 32143 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin siglling and insulin siglling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. In , in the experimental high glucose condition, APPL1 acts as a protective factor against podocytes injury through regulating AMPK sigling, and may be a new therapy target for diabetic nephropathy. | 26261560 |
| Atherosclerosis | 1. a potential role of adiponectin/APPL1 signaling in mediating the effect of incretin in the prevention of atherosclerosis progression or plaque vulnerability in T2DM. | 27771154 |