| AQP1 |
| LOCUS ID | 358 | ||||||||||
| GENE_SYMBOL | AQP1 | ||||||||||
| GENE NAME | aquaporin 1 (Colton | ||||||||||
| SYNONYMNS | CO, CHIP28, AQP-CHIP | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 68051 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Sever |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Glial fibrillary acidic protein and AQP1 showed an approximate 2-fold increase, whereas AQP4 showed an approximate 25-fold increase in diabetics with DR versus controls. | 26087356 |