| AQP4 |
| LOCUS ID | 361 | ||||||||||
| GENE_SYMBOL | AQP4 | ||||||||||
| GENE NAME | aquaporin 4 | ||||||||||
| SYNONYMNS | MIWC, WCH4 | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 37507 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predomint aquaporin found in brain and has an important role in brain water homeostasis. Altertively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translatiol readthrough in this gene and expression of an additional C-termilly extended |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. streptozotocin injection induced diabetes resulted in compensatory increases of AQP4 expression, and downregulation of AQP4 exacerbated diabetic retinopathy through aggravating inflammatory response, at last in part. Therefore, regulation of retinal function by AQP4 may attenuate diabetic retinopathy, offering a promising therapeutic strategy for diabetic retinopathy. | 22449442 |