| ARG1 |
| LOCUS ID | 383 | ||||||||||
| GENE_SYMBOL | ARG1 | ||||||||||
| GENE NAME | arginase 1 | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Arginase?catalyzes?the?hydrolysis?of?arginine?to?ornithine?and?urea.?At?least?two?isoforms?of?mammalian?arginase?exist?(types?I?and?II)?which?differ?in?their?tissue?distribution,?subcellular?localization,?immunologic?crossreactivity?and?physiologic?function.?The?type?I?isoform?encoded?by?this?gene,?is?a?cytosolic?enzyme?and?expressed?predominantly?in?the?liver?as?a?component?of?the?urea?cycle.?Inherited?deficiency?of?this?enzyme?results?in?argininemia,?an?autosomal?recessive?disorder?characteriz |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The FXO supplementation suppresses immune cell infiltration into adipose tissue and alters adipose tissue macrophage phenotype towards the anti-inflammatory state via enhancement of E and D series resolvins, arginase 1 expression and anti-inflammatory cytokines level (IL-4 and IL-10.) leading to amelioration of insulin resistance in flaxseed oil supplemented HFD mice. | 31622373 |