| ARG2 |
| LOCUS ID | 384 | ||||||||||
| GENE_SYMBOL | ARG2 | ||||||||||
| GENE NAME | arginase 2 | ||||||||||
| SYNONYMNS | |||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 906 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. arginase 2 (Arg2) as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose intolerance in obese murine models | 30962478 |