| ARL15 |
| LOCUS ID | 54622 | |||||||||||||
| GENE_SYMBOL | ARL15 | |||||||||||||
| GENE NAME | ADP ribosylation fac | |||||||||||||
| SYNONYMNS | ARFRP2 | |||||||||||||
| CHROMOSOME | 5 | |||||||||||||
| HOMOLOGENE ID | 56843 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| ARL15 (ADP Ribosylation Factor Like GTPase 15) is a Protein Coding gene. Diseases associated with ARL15 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Lipodystrophy, Familial Partial, Type 1. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARF6. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Recently, genomic studies have found that ARL15, and some of its common genetic variants are associated with type 2 diabetes and coronary atherosclerosis. | 30682341 |
| Insulin resistance and inflammation | 1. CONCLUSIONS: This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology. | 29465355 |