| ATF2 |
| LOCUS ID | 1386 | ||||||||||
| GENE_SYMBOL | ATF2 | ||||||||||
| GENE NAME | activating transcrip | ||||||||||
| SYNONYMNS | HB16 CREB2 TREB7 CREB-2 CRE-BP1 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 31061 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetyla |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. we show that ATF2 protein was significantly more induced in WAT of ob/ob mice compared with C57BL/6J mice. | 23712976 |