| ATF6 |
| LOCUS ID | 22926 | ||||||||||
| GENE_SYMBOL | ATF6 | ||||||||||
| GENE NAME | activating transcrip | ||||||||||
| SYNONYMNS | ACHM7 ATF6A | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 32015 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is presen |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Chronic ER stress was significantly reduced (ATF6-CHOP, JNK-P) and expression levels of SIRT1 and GRP78 - a Ca2+-dependent chaperone - were increased and accompanied by the restoration of Ca2+ depots. | 30385096 |