| B2M |
| LOCUS ID | 567 | |||||||||||||
| GENE_SYMBOL | B2M | |||||||||||||
| GENE NAME | beta-2-microglobulin | |||||||||||||
| SYNONYMNS | IMD43 | |||||||||||||
| CHROMOSOME | 15 | |||||||||||||
| HOMOLOGENE ID | 2987 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Higher serum B2M was an independent risk factor for subclinical atherosclerosis and diabetic nephropathy in patients with T2D without renal impairment. | 25303803 |
| Atherosclerosis | 1. Higher serum B2M was an independent risk factor for subclinical atherosclerosis and diabetic nephropathy in patients with T2D without renal impairment. | 25303803 |