| BAAT |
| LOCUS ID | 570 | ||||||||||
| GENE_SYMBOL | BAAT | ||||||||||
| GENE NAME | bile acid-CoA:amino | ||||||||||
| SYNONYMNS | BAT, BACAT | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 1286 |
| microRNAs | miR-328 | 26900752 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestil tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for th |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Moreover, due to its ability to oxidize glucose and lipids, BAT activation has been considered a potential therapy to combat type 2 diabetes and atherogenesis. | 26227180 |