| BACE1 |
| LOCUS ID | 23621 | ||||||||||
| GENE_SYMBOL | BACE1 | ||||||||||
| GENE NAME | beta-secretase 1 | ||||||||||
| SYNONYMNS | ASP2 BACE HSPC104 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 8014 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer& |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We show that BACE1 inhibition or knockdown attenuates palmitate-induced endoplasmic reticulum (ER) stress, inflammation, and insulin resistance and prevents the reduction in Peroxisome Proliferator-Activated Receptor ? Co-activator 1? (PGC-1? ) and fatty acid oxidation caused by palmitate in myotubes. | 29526536 |