| BASP1 |
| LOCUS ID | 10409 | ||||||||||
| GENE_SYMBOL | BASP1 | ||||||||||
| GENE NAME | brain abundant, memb | ||||||||||
| SYNONYMNS | CAP23, P22, CAP-23, P-22 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 38168 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-termil myristoylation. Altertive splicing results in multiple transcript variants that encode the same protein. [provid |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Supporting possible involvement of BASP1 in renal disease other than DN, we also observed significant upregulation of renal BASP1 in spontaneously hypertensive rats and a trend toward increased tubulointerstitial BASP1 mRNA in human hypertensive nephropathy. a combined functional genomics approach identified BASP1 as a proapoptotic factor in DN and possibly also in hypertensive nephropathy. | 20110383 |