| BCL2 |
| LOCUS ID | 596 | |||||||||||||
| GENE_SYMBOL | BCL2 | |||||||||||||
| GENE NAME | B-cell CLL/lymphoma | |||||||||||||
| SYNONYMNS | Bcl-2, PPP1R50 | |||||||||||||
| CHROMOSOME | 18 | |||||||||||||
| HOMOLOGENE ID | 527 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alterte splicing, differ in their C-termil ends. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Accordingly, BCL2 levels were found elevated and caspase-3 and caspase-8 levels decreased in the diabetic group. | 21983986 |
| Insulin resistance and inflammation | 1. The expression levels of initiator (CASP8/9) and effector (CASP3/7) caspases as well as antiapoptotic B-cell lymphoma (BCL)2 and inflammatory markers were assessed in visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with different degrees of obesity and without insulin resistance or diabetes. | 23193206 |