| BDKRB1 |
| LOCUS ID | 623 | |||||||||||||
| GENE_SYMBOL | BDKRB1 | |||||||||||||
| GENE NAME | bradykinin receptor | |||||||||||||
| SYNONYMNS | B1R, BKR1, B1BKR, BKB1R, BDKRB2, BRADYB1 | |||||||||||||
| CHROMOSOME | 14 | |||||||||||||
| HOMOLOGENE ID | 570 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acu |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.We have therefore explored the influence of lack of both bradykinin receptors (B1R and B2R) on diabetic nephropathy, neuropathy, and osteopathy in male mice heterozygous for the Akita diabetogenic mutation in the insulin 2 gene (Ins2) | 20479236 |
| Retinopathy | 1. For the first time, we showed that BDKRB1 rs12050217 G allele is associated with protection for the advanced stage of DR in T2DM patients; however, further studies are needed to confirm this finding. | 31017477 |