| BDKRB2 |
| LOCUS ID | 624 | ||||||||||
| GENE_SYMBOL | BDKRB2 | ||||||||||
| GENE NAME | bradykinin receptor | ||||||||||
| SYNONYMNS | B2R, BK2, BK-2, BKR2, BRB2 | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 519 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alterte start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.We have therefore explored the influence of lack of both bradykinin receptors (B1R and B2R) on diabetic nephropathy, neuropathy, and osteopathy in male mice heterozygous for the Akita diabetogenic mutation in the insulin 2 gene (Ins2) | 20479236 |