| BGLAP |
| LOCUS ID | 632 | ||||||||||
| GENE_SYMBOL | BGLAP | ||||||||||
| GENE NAME | bone gamma-carboxygl | ||||||||||
| SYNONYMNS | OC BGP OCN | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 104130 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encod |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Osteocalcin (OCN) acts as a bone-derived hormone promoting insulin sensitivity and glucose tolerance , ?-carboxylation of OCN on Glu17 residue correlates with insulin resistance and subclinical inflammation, suggesting that ?-carboxylation of OCN negatively regulates its endocrine action in humans. | 28242268 |