| BMP4 |
| LOCUS ID | 652 | |||||||||||||
| GENE_SYMBOL | BMP4 | |||||||||||||
| GENE NAME | bone morphogenetic p | |||||||||||||
| SYNONYMNS | ZYME,BMP2B,OFC11,BMP2B1,MCOPS6 | |||||||||||||
| CHROMOSOME | 14 | |||||||||||||
| HOMOLOGENE ID | 7247 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were origilly identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in h |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Here, we show that BMP4 may act as an upstream regulatory molecule for the process of extracellular matrix (ECM) accumulation in Diabetic nephropathy (DN) and thereby reveals a new aspect of the molecular mechanisms involved in DN. | 21471216 |
| Insulin resistance and inflammation | 1. In vitro, BMP4 expression in cultured human adipocytes is upregulated after induction of differentiation. | 26228459 |