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BNIP3 |
LOCUS ID | 664 | ||||||||||
GENE_SYMBOL | BNIP3 | ||||||||||
GENE NAME | BCL2/adenovirus E1B | ||||||||||
SYNONYMNS | NIP3 | ||||||||||
CHROMOSOME | 10 | ||||||||||
HOMOLOGENE ID | 2990 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by D methylation. [provided by RefSeq, Dec 2014] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Cardiovascular | 1. BNIP3 could therefore serve as a potential drug target against diabetic macrovascular complications and, in particular, DCM | 26170914 |