| CACNA1H |
| LOCUS ID | 8912 | ||||||||||
| GENE_SYMBOL | CACNA1H | ||||||||||
| GENE NAME | calcium voltage-gate | ||||||||||
| SYNONYMNS | ECA6, EIG6, Cav3.2, CACNA1HB | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 56913 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either en |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. CaV3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (nociceptors) in response to hyperglycemia associated with diabetes, which in turn can be a basis for painful symptoms of peripheral diabetic neuropathy (PDN). | 23835327 |