| CARD9 |
| LOCUS ID | 64170 | ||||||||||
| GENE_SYMBOL | CARD9 | ||||||||||
| GENE NAME | caspase recruitment | ||||||||||
| SYNONYMNS | CANDF2 hCARD9 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 14150 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF- |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CARD9 knockout alleviated HFD-induced insulin resistance and glucose intolerance, prevented myocardial dysfunction with preserved cardiac fractional shortening and cardiomyocyte contractile properties. | 26900039 |