CARD9
LOCUS ID64170
GENE_SYMBOLCARD9
GENE NAMEcaspase recruitment
SYNONYMNSCANDF2 hCARD9
CHROMOSOME9
HOMOLOGENE ID14150
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. CARD9 knockout alleviated HFD-induced insulin resistance and glucose intolerance, prevented myocardial dysfunction with preserved cardiac fractional shortening and cardiomyocyte contractile properties. 26900039