| CASP1 |
| LOCUS ID | 834 | ||||||||||
| GENE_SYMBOL | CASP1 | ||||||||||
| GENE NAME | caspase 1 | ||||||||||
| SYNONYMNS | ICE P45 IL1BC | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 133272 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleu |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CASPASE-1 mRNA and the proportion of T(h)1 transcripts (TBX21/CD3?) were significantly higher in AT from obese compared with lean subjects. | 22325453 |