| CAST |
| LOCUS ID | 831 | ||||||||||
| GENE_SYMBOL | CAST | ||||||||||
| GENE NAME | calpastatin | ||||||||||
| SYNONYMNS | BS-17 PLACK | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 7658 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of ge |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CAST overexpression significantly reduced adipocyte apoptosis, adipose tissue collagen and macrophage accumulation. | 29089532 |