| CAV1 |
| LOCUS ID | 857 | |||||||||||||
| GENE_SYMBOL | CAV1 | |||||||||||||
| GENE NAME | caveolin 1 | |||||||||||||
| SYNONYMNS | CGL3, PPH3, BSCL3, LCCNS, VIP21, MSTP085 | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 1330 |
| microRNAs | miR-103/107 | 21654750 |
| GENE SUMMARY |
|---|
| The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The third network portrays unique interactions PTPN1 with EGFR and CAV1 which could lead to an impaired vascular function in diabetic nephropathy condition. | 19997558 |
| Neuropathy | 1. increased Erb B2 activity contributes to specific indexes of DPN, and Cav1 may be an endogenous regulator of Erb B2 signaling. Altered Erb B2 signaling is a novel mechanism that contributes to SC dysfunction in diabetes, and inhibiting Erb B2 may ameliorate deficits of tactile sensitivity in DPN | 19675140 |