| CCL20 |
| LOCUS ID | 6364 | |||||||||||||
| GENE_SYMBOL | CCL20 | |||||||||||||
| GENE NAME | chemokine (C-C motif | |||||||||||||
| SYNONYMNS | CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20, MIP-3-alp | |||||||||||||
| CHROMOSOME | 2 | |||||||||||||
| HOMOLOGENE ID | 3375 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| not availabe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. KLF6 overexpression increased MIP-3alpha which was inhibited by concurrent exposure to PPAR-gamma agonists. PPAR-gamma agonists attenuated high glucose-induced MIP-3alpha secretion.The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN.Macrophage inflammatory protein-3 alpha (MIP-3alpha) is known to be upregulated early in the development of diabetic nephropathy (DN).The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN. | 21109018 |
| Insulin resistance and inflammation | 1. CCL20 neutralization or CCR6 deficiency reduces the Th17 population or insulin resistance in T-HGK cKO mice. | 25098764 |