| CCL3 |
| LOCUS ID | 6348 | ||||||||||
| GENE_SYMBOL | CCL3 | ||||||||||
| GENE NAME | C-C motif chemokine | ||||||||||
| SYNONYMNS | MIP1A SCYA3 G0S19-1 LD78ALPHA MIP-1-alpha | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 88430 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. RT-qPCR analysis of key markers of inflammation revealed a three- to fivefold increase in TNF? and CCL3, confirming the presence of inflammation. | 25566190 |