| CCN3 |
| LOCUS ID | 4856 | ||||||||||
| GENE_SYMBOL | CCN3 | ||||||||||
| GENE NAME | cellular communicati | ||||||||||
| SYNONYMNS | NOV NOVh IBP-9 IGFBP9 IGFBP-9 | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 1884 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The metabolic abnormalities in NASH are driven by decreased levels of hepatic HO-1 that is associated with an increase in the adipose-derived proinflammatory adipokine NOV in our obese mouse model of NASH. | 30057822 |