| CCN4 |
| LOCUS ID | 8840 | ||||||||||
| GENE_SYMBOL | CCN4 | ||||||||||
| GENE NAME | cellular communicati | ||||||||||
| SYNONYMNS | WISP1 WISP1c WISP1i WISP1tc WISP1-OT1 WISP1-UT1 | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 2883 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-l |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Knockdown of WISP1 in high-fat diet-fed C57BL/6 mice significantly reduced (0.45-0.5%; p < 0.05) inflammation and JNK phosphorylation (45-50%; P < 0.01) and attenuated hepatic steatosis (approximately 55%; p < 0.001) and skeletal muscle insulin resistance (30-40%; p < 0.05). | 29319180 |