| CCN5 |
| LOCUS ID | 8839 | ||||||||||
| GENE_SYMBOL | CCN5 | ||||||||||
| GENE NAME | cellular communicati | ||||||||||
| SYNONYMNS | CT58 WISP2 CTGF-L | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 2882 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-l |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Knocking down WISP2 induced spontaneous differentiation of 3T3-L1 and human preadipocytes and allowed NIH 3T3 fibroblasts to become committed to the adipose lineage by bone morphogenetic protein 4 (BMP4). | 23359679 |