| CCR6 |
| LOCUS ID | 1235 | ||||||||||
| GENE_SYMBOL | CCR6 | ||||||||||
| GENE NAME | C-C motif chemokine | ||||||||||
| SYNONYMNS | BN-1 DCR2 DRY6 CCR-6 CD196 CKRL3 GPR29 CKR-L3 CMKBR6 GPRCY4 STRL22 CC-CKR-6 C-C CKR-6 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 3214 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of de |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CCL20 neutralization or CCR6 deficiency reduces the Th17 population or insulin resistance in T-HGK cKO mice. | 25098764 |