| CCR7 |
| LOCUS ID | 1236 | ||||||||||
| GENE_SYMBOL | CCR7 | ||||||||||
| GENE NAME | C-C motif chemokine | ||||||||||
| SYNONYMNS | BLR2 EBI1 CCR-7 CD197 CDw197 CMKBR7 CC-CKR-7 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 1387 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Here we show that obesity promotes the accumulation of CD11c(+) adipose tissue immune cells that express C-C chemokine receptor 7 (CCR7) in mice and humans, and that CCR7 contributes to chronic inflammation and insulin resistance. | 27207557 |