| CD14 |
| LOCUS ID | 929 | |||||||||||||
| GENE_SYMBOL | CD14 | |||||||||||||
| GENE NAME | CD14 molecule | |||||||||||||
| SYNONYMNS | ||||||||||||||
| CHROMOSOME | 5 | |||||||||||||
| HOMOLOGENE ID | 493 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. Reduced MARCO and CD14 expression contributes to defective sentinel function of alveolar macrophages, promoting tuberculosis susceptibility in diabetic hosts at a critical early step in the immune response to aerosol infection | 27630197 |
| Insulin resistance and inflammation | 1. CD14 gene expression was increased in whole adipose tissue and adipocytes from obese humans and further increased after tumor necrosis factor-?. | 21700881 |