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CD163 |
LOCUS ID | 9332 | |||||||||||||||||||
GENE_SYMBOL | CD163 | |||||||||||||||||||
GENE NAME | CD163 molecule | |||||||||||||||||||
SYNONYMNS | M130, MM130 | |||||||||||||||||||
CHROMOSOME | 12 | |||||||||||||||||||
HOMOLOGENE ID | 128811 |
microRNAs | NA | NA |
GENE SUMMARY |
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The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Altern |
OBSERVATIONS |
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Complication | Evidence | PMID |
Retinopathy | 1. The concentrations of sCD163 and periostin in the vitreous were significantly higher in patients with PDR than in non-diabetic controls (p<0.0001)These findings indicate that the overexpression of CD163 by macrophages may be involved in the development of FVMs partly through periostin production. | 25281471 |
Atherosclerosis | 1. Cardiovascular disease is associated with increased sCD163/sTWEAK ratio. | 26433887 |
Neuropathy | 1. Higher levels of soluble CD163 in people with diabetic polyneuropathy suggest that inflammation plays a role in the development of neural impairment. The relationship between cerebrospinal fluid soluble CD163 level and peripheral nerve conduction indicates that soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy. | 25156085 |
Insulin resistance and Inflammation | 1. In exercised overweight/obese individuals, expression of genes for three anti-inflammatory macrophage markers, MGL (p = 0.0031, ? = 0.71), CD163 (p = 0.0268, ? = 0.57) and mannose receptor (p = 0.0125, ? = 0.63), correlated with high glucose-disposal rate. | 23595247 |