| CD209 |
| LOCUS ID | 30835 | ||||||||||
| GENE_SYMBOL | CD209 | ||||||||||
| GENE NAME | CD209 molecule | ||||||||||
| SYNONYMNS | CDSIGN CLEC4L DC-SIGN DC-SIGN1 hDC-SIGN | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 128353 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The level of phosphorylated c-Jun N-terminal kinases (JNK) was significantly increased by LECT2 treatment in HUVECs (Human umbilical vein endothelial cells) and THP-1 cells, an effect that was not seen in cells treated with CD209 siRNA, a known LECT2 receptor. | 26123523 |