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CD28 |
LOCUS ID | 940 | |||||||||||||
GENE_SYMBOL | CD28 | |||||||||||||
GENE NAME | CD28 molecule | |||||||||||||
SYNONYMNS | Tp44 | |||||||||||||
CHROMOSOME | 2 | |||||||||||||
HOMOLOGENE ID | 4473 |
microRNAs | NA | NA |
GENE SUMMARY |
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The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Tuberculosis | 1. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility. | 22230325 |
Insulin resistance and inflammation | 1. Cd28KO epididymal but not subcutaneous fat was characterized by enlarged adipocytes, reduced levels of inflammatory cytokines and increased Glut4, adiponectin and lipogenic enzyme mRNA levels. | 25771927 |