| CD3E |
| LOCUS ID | 916 | ||||||||||
| GENE_SYMBOL | CD3E | ||||||||||
| GENE NAME | CD3e molecule | ||||||||||
| SYNONYMNS | T3E TCRE IMD18 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 586 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. CASPASE-1 mRNA and the proportion of T(h)1 transcripts (TBX21/CD3?) were significantly higher in AT from obese compared with lean subjects. | 22325453 |