| CD4 |
| LOCUS ID | 920 | ||||||||||||||||
| GENE_SYMBOL | CD4 | ||||||||||||||||
| GENE NAME | CD4 molecule | ||||||||||||||||
| SYNONYMNS | CD4mut | ||||||||||||||||
| CHROMOSOME | 12 | ||||||||||||||||
| HOMOLOGENE ID | 513 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damag |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Statin users had more cardiovascular risk factors and a lower CD4 T cell nadir than statin non-users. | 26200661 |
| Atherosclerosis | 1. Cerebral atherosclerosis accounted for one-quarter of the brain infarcts in HIV+ cases, and was more common with aging, diabetes, a lower CD4 nadir, and a higher antemortem CD4 count. | 26320196 |
| Insulin resistance and inflammation | 1. Results showed that CD4 and CD8 T cells infiltrate both depots, with proinflammatory T-helper (Th)-1, Th17, and CD8 T cells, significantly more frequent in VAT as compared with SAT. | 25341798 |