CD44
LOCUS ID960
GENE_SYMBOLCD44
GENE NAMECD44 molecule (India
SYNONYMNSIN LHR MC56 MDU2 MDU3 MIC4 Pgp1 CDW44 CSPG8 HCELL HUTCH-I ECMR-III
CHROMOSOME11
HOMOLOGENE ID508
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative s

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. We recently applied a bioinformatics methodology to open public data and found that CD44 plays a critical role in the development of adipose tissue inflammation and insulin resistance.25294945