| CD44 |
| LOCUS ID | 960 | ||||||||||
| GENE_SYMBOL | CD44 | ||||||||||
| GENE NAME | CD44 molecule (India | ||||||||||
| SYNONYMNS | IN LHR MC56 MDU2 MDU3 MIC4 Pgp1 CDW44 CSPG8 HCELL HUTCH-I ECMR-III | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 508 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative s |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We recently applied a bioinformatics methodology to open public data and found that CD44 plays a critical role in the development of adipose tissue inflammation and insulin resistance. | 25294945 |