| CD59 |
| LOCUS ID | 966 | ||||||||||
| GENE_SYMBOL | CD59 | ||||||||||
| GENE NAME | CD59 molecule, compl | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 56386 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in th |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Recent studies have described elevated levels of membrane attack complex (MAC) and reduced levels of membrane associated complement regulators including CD55 and CD59 in the retina of diabetic retinopathy patients as well as in animal models of this disease. | 24167638 |