| CD80 |
| LOCUS ID | 941 | ||||||||||
| GENE_SYMBOL | CD80 | ||||||||||
| GENE NAME | CD80 molecule | ||||||||||
| SYNONYMNS | B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 3804 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Here, we show that the immune-related molecule B7-1/CD80 is a critical mediator of podocyte injury in type 2 diabetic nephropathy. | 24676639 |