| CD86 |
| LOCUS ID | 942 | ||||||||||
| GENE_SYMBOL | CD86 | ||||||||||
| GENE NAME | CD86 molecule | ||||||||||
| SYNONYMNS | B70 B7-2 B7.2 LAB72 CD28LG2 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 10443 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and dim |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. These findings indicate that CD40 signaling in adipose tissue macrophages regulates major histocompatibility complex class II and CD86 expression to control the expansion of CD4(+) T cells; however, this is largely dispensable for the development of obesity-induced inflammation and insulin resistance in mice. | 26658005 |