| CD8A |
| LOCUS ID | 925 | ||||||||||
| GENE_SYMBOL | CD8A | ||||||||||
| GENE NAME | CD8a molecule | ||||||||||
| SYNONYMNS | CD8 p32 Leu2 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 133777 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Adipose messenger ribonucleic acid expression of inflammatory genes including CD68, leptin, matrix metalloproteinase-9, CD163, and CD8A were significantly greater and vascular endothelial growth factor was lower in the CLS+ (presence (+) of macrophage crown-like structures (CLS) in subcutaneous abdominal fat biopsy) group (p < 0.05). | 21737012 |