| CDH1 |
| LOCUS ID | 999 | ||||||||||
| GENE_SYMBOL | CDH1 | ||||||||||
| GENE NAME | cadherin 1, type 1 | ||||||||||
| SYNONYMNS | UVO, CDHE, ECAD, LCAM, Arc-1, CD324 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 20917 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a classical cadherin of the cadherin superfamily. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovar |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. We provide compelling evidence that TGF-beta 1-induced EMT instigates a loss of E-cadherin, cell adhesion and ultimately of connexin-mediated cell communication in the proximal tubule under diabetic conditions; these changes occur ahead of overt signs of renal damage. 2. Decreased expression of P- and E-cadherins is implicated in podocyte dysfunction and epithelial-mesenchymal transition observed in DN. We speculate that the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN. | 22215279 |