CDH1
LOCUS ID999
GENE_SYMBOLCDH1
GENE NAMEcadherin 1, type 1
SYNONYMNSUVO, CDHE, ECAD, LCAM, Arc-1, CD324
CHROMOSOME16
HOMOLOGENE ID20917
microRNAsNANA
GENE SUMMARY
This gene encodes a classical cadherin of the cadherin superfamily. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovar

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We provide compelling evidence that TGF-beta 1-induced EMT instigates a loss of E-cadherin, cell adhesion and ultimately of connexin-mediated cell communication in the proximal tubule under diabetic conditions; these changes occur ahead of overt signs of renal damage. 2. Decreased expression of P- and E-cadherins is implicated in podocyte dysfunction and epithelial-mesenchymal transition observed in DN. We speculate that the actions of GH on ZEB2 and P- and E-cadherin expression play a role in the pathogenesis of microalbuminuria of DN.22215279