| CDH13 |
| LOCUS ID | 1012 | ||||||||||
| GENE_SYMBOL | CDH13 | ||||||||||
| GENE NAME | cadherin 13 | ||||||||||
| SYNONYMNS | CDHH, P105 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 20335 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Overall, 10 single nucleotide polymorphisms (SNPs) in ADIPOQ and CDH13 susceptibility loci were associated with DR. Gene risk score (GRS) was calculated based on 10 SNPs for each subject and the cumulative effect of genes was observed. | 30882695 |