| CDH2 |
| LOCUS ID | 1000 | ||||||||||
| GENE_SYMBOL | CDH2 | ||||||||||
| GENE NAME | cadherin 2, type 1, | ||||||||||
| SYNONYMNS | CDHN, NCAD, CD325, CDw325 | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 20424 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a classical cadherin and member of the cadherin superfamily. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. It was shown that CTGF, MCP-1, PAI-1, ACE, CDH1, CDH2 mRNA varied significantly among the 3 study groups, and their mRNA levels increased with DN progression (p<0.05). | 22629296 |