| CDK4 |
| LOCUS ID | 1019 | ||||||||||
| GENE_SYMBOL | CDK4 | ||||||||||
| GENE NAME | cyclin dependent kin | ||||||||||
| SYNONYMNS | CMM3, PSK-J3 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 55429 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphoryla |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Thus, atherosclerosis complications in T2DM associate with altered immune cell homeostasis, diminished CDKN2A/2B/2BAS expression, and increased CDK4 levels. | 30176239 |