| CDK7 |
| LOCUS ID | 1022 | ||||||||||
| GENE_SYMBOL | CDK7 | ||||||||||
| GENE NAME | cyclin-dependent kin | ||||||||||
| SYNONYMNS | CAK1, HCAK, MO15, STK1, CDKN7, p39MO15 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1363 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcri |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. In the kidneys of the GK rat, a model of type II diabetes, CDK7 showed a steady age-related increase in mRNA , increasing to >sixfold in 40 week GK rats compared to normoglycemic age-matched Wistar rat kidneys, this increase correlates with progressive hyperglycemia. | 17416350 |