| CDKN1A |
| LOCUS ID | 1026 | ||||||||||
| GENE_SYMBOL | CDKN1A | ||||||||||
| GENE NAME | cyclin-dependent kin | ||||||||||
| SYNONYMNS | P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 333 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PC |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. At the cell-cycle level, the HG-induced proliferation of MCs was associated with a decrease in cyclin dependent kinase (CDK) inhibitor p21 protein expression accompanied by an increase in CDK4 and CDK2 kinase activities. 2. The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathypotential role in glomerular hypertroph These results support a role for p21 in causing glomerular cell hypertrophy in diabetic nephropathy. | 12048257 |